Association of salivary sCD14 concentration levels with early childhood caries.
| Autor: | Biria M; Department of Pediatric Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran, e-mail: dr.biriam@gmail.com., Sattari M, Vahid Golpayegani M, Kooshki F |
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| Jazyk: | angličtina |
| Zdroj: | Iranian journal of immunology : IJI [Iran J Immunol] 2010 Sep; Vol. 7 (3), pp. 193-7. |
| DOI: | IJIv7i3A7 |
| Abstrakt: | Background: Early childhood caries (ECC) is a severe type of dental caries affecting infants and pre-school children. Because of the infectious nature of the disease, the immunologic response by the host plays an essential role in its development. Objective: This study investigated the association between the presence of salivary sCD14 and ECC. Methods: This study was carried out on 40 healthy children, of whom 20 were caries-free (CF) and 20 had ECC, within the ages of 36 to 71 months. Unstimulated saliva of the children was collected with disposable needle-less syringe from buccal and labial vestibules. Seven children with ECC received complete treatments. Saliva was collected for a second time after 3 months from this group. The sCD14 levels in salivary samples were analyzed by ELISA method. Results: Mean concentrations of sCD14 in ECC and CF groups were 57.82 and 31.92 ng/ml respectively (p=0.008). After three months, the mean concentration of sCD14 among the treated children decreased to 11.38 ng/ml, which was significantly lower compared to that of ECC children before intervention (p<0.001), and also CF children (p<0.05). Conclusion: The increased levels of sCD14 can be considered as a marker of inflammation and innate immune response during ECC. |
| Databáze: | MEDLINE |
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