Seroprevalence of antibodies to hepatitis E virus in two large communities in Havana, Cuba.

Autor:	Villalba MC; National Reference Laboratory on Viral Hepatitis, Institute of Tropical Medicine 'Pedro Kour' (IPK), Autopista Novia del Mediodía Km 6 ½ e/ Autopista Nacional y Carretera Central, La Lisa. P.O. Box 601, Marianao 13, Havana City, Cuba. mcary@ipk.sld.cu, Guan M, Pérez A, Corredor MB, Frometa SS, Moreno AG, Hu WP, Howard T, Lay LA, Anderson D
Jazyk:	angličtina
Zdroj:	Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2010 Dec; Vol. 104 (12), pp. 772-6. Date of Electronic Publication: 2010 Sep 25.
DOI:	10.1016/j.trstmh.2010.08.006
Abstrakt:	Hepatitis E virus (HEV) infection is an important cause of acute viral hepatitis in tropical and sub-tropical regions that occurs both as epidemic episodes and sporadic cases. The aim of this investigation was to estimate the prevalence of total immunoglobulin (Ig) anti-hepatitis E virus (anti-HEV) and the risk factors associated to two communities in Havana City. Serum samples (n=469) obtained from healthy individuals with no history of viral hepatitis were screened for total anti-HEV by enzyme immunoassay (EIA). An overall prevalence of 10% (47/469) (95% CI; 7.52-13.19%) was obtained. Higher anti-HEV prevalence was found in the municipality of Marianao (12.1%) compared to Playa (7.1%). Analysis of risk factors revealed a significant association of total anti-HEV prevalence in age group 41-60 years old, with a risk ratio of 3.21 (95% CI: 1.09-9.7) (P=0.01). No relation was found between anti-HEV and other variables such as gender, risk occupations, surgery and transfusions. The detection of total anti-HEV in individuals with no overt acute hepatitis suggests the existence of sub-clinical or anicteric HEV infection in these municipalities. (Copyright © 2010 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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