| Autor: |
Guevorkian K; UMR 168, Institut Curie/CNRS, Université Pierre et Marie Curie, 75248 Paris, France., Colbert MJ, Durth M, Dufour S, Brochard-Wyart F |
| Jazyk: |
angličtina |
| Zdroj: |
Physical review letters [Phys Rev Lett] 2010 May 28; Vol. 104 (21), pp. 218101. Date of Electronic Publication: 2010 May 24. |
| DOI: |
10.1103/PhysRevLett.104.218101 |
| Abstrakt: |
Spherical cellular aggregates are in vitro systems to study the physical and biophysical properties of tissues. We present a novel approach to characterize the mechanical properties of cellular aggregates using a micropipette aspiration technique. We observe an aspiration in two distinct regimes: a fast elastic deformation followed by a viscous flow. We develop a model based on this viscoelastic behavior to deduce the surface tension, viscosity, and elastic modulus. A major result is the increase of the surface tension with the applied force, interpreted as an effect of cellular mechanosensing. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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