Development of photostable near-infrared cyanine dyes.

Autor: Samanta A; Department of Chemistry & MedChem Program of Life Sciences Institute, National University of Singapore, 117543, Singapore., Vendrell M, Das R, Chang YT
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2010 Oct 21; Vol. 46 (39), pp. 7406-8. Date of Electronic Publication: 2010 Sep 08.
DOI: 10.1039/c0cc02366c
Abstrakt: With the emerging interest in optical in vivo imaging, there is an increasing demand of photostable near-infrared (NIR) dyes. Herein we report the rational design of an amine tricarbocyanine structure with improved photostability (CyNA) and its combinatorial derivatization to render CyNA-414 as a NIR-fluorescent dye with stronger emission intensity and higher photostability than the NIR standard IndoCyanine Green (ICG).
Databáze: MEDLINE