| Autor: |
Wang J; Division of Medical Oncology and Hematology, Loma Linda University Medical Center, Loma Linda, CA 92354, USA., Saukel GW, Garberoglio CA, Srikureja W, Hsueh CT |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of hematology & oncology [J Hematol Oncol] 2010 Sep 09; Vol. 3, pp. 31. Date of Electronic Publication: 2010 Sep 09. |
| DOI: |
10.1186/1756-8722-3-31 |
| Abstrakt: |
We report a 49-year-old Chinese male with locally advanced gastric adenocarcinoma achieving pathological complete response after neoadjuvant chemotherapy with trastuzumab-containing regimen. He underwent esophagogastroduodenoscopy in September 2009, which revealed a 2-cm gastric ulcer on the lesser curvature proximal to angularis. Biopsy of gastric ulcer showed moderately differentiated adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry and fluorescence in situ hybridization. Further workups with endoscopic ultrasound, computed tomography and positron emission tomography staged his cancer as T3N1M0. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, docetaxel and capecitabine without severe toxicities except grade 2 diarrhea near the completion of cycle 3 requiring discontinuation of capecitabine. Afterwards, he received total gastrectomy with extended D2 lymph node dissections showing pathological complete response. He went on to receive 3 more cycles of chemotherapy postoperatively. The role of trastuzumab as a part of perioperative therapy in gastric cancer overexpressing HER2 is worth further investigation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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