Phosphodiesterase inhibitor effect on small artery function in preeclampsia.

Autor: Samangaya RA; Maternal & Fetal Health Research Centre, St. Mary's Hospital, Manchester, UK. rasmith@doctors.net.uk, Wareing M, Skillern L, Baker PN
Jazyk: angličtina
Zdroj: Hypertension in pregnancy [Hypertens Pregnancy] 2011; Vol. 30 (2), pp. 144-52. Date of Electronic Publication: 2010 Sep 06.
DOI: 10.3109/10641955.2010.484083
Abstrakt: Objective: To determine if the phosphodiesterase type 5 inhibitor, sildenafil citrate improves endothelial-dependent relaxation of small arteries from women with preeclampsia.
Methods: Myometrial and omental biopsies were taken from women participating in a randomized placebo-controlled trial using sildenafil citrate in women with preeclampsia. Vasoconstriction and endothelial-dependent relaxation of small arteries was measured utilizing wire myography.
Results: Vasoconstriction and endothelial-dependent relaxation of myometrial and omental arteries were not altered in women taking sildenafil.
Conclusion: Acute effects may have been lost as sildenafil administration occurred many hours prior to myography. Plasma sildenafil levels may have been lower than required for vascular response.
Databáze: MEDLINE
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