| Autor: |
Grigorova LV, Rozkin MIa, Rybin VK, Efimov VS, Makarov NV |
| Jazyk: |
ruština |
| Zdroj: |
Farmakologiia i toksikologiia [Farmakol Toksikol] 1990 Nov-Dec; Vol. 53 (6), pp. 31-3. |
| Abstrakt: |
The comparative study of the antiheparin activity and acute toxicity of the commercial preparation stellin and its homogeneous fractions was carried out. The summary preparation stellin along with a low antiheparin activity possessed a high toxicity explained by the content of ballast proteins of the nonprotamin nature. One of the homogeneous fractions--stellin B had the best antiheparin properties (heparin neutralizing ratio of 8:1 w:w) and a low toxicity due to a high content of arginine residues and a rigid macromolecular structure facilitating the interpolymer interaction with heparin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
