Cytokine expression in the duodenal mucosa of patients with visceral leishmaniasis.
| Autor: | Luz KG; Department of Infectious Diseases, Federal University of Rio Grande do Norte, Natal, RN, Brazil. luz@ufrnet.br, Tuon FF, Duarte MI, Maia GM, Matos P, Ramos AM, Nicodemo AC |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2010 Jul-Aug; Vol. 43 (4), pp. 393-5. |
| DOI: | 10.1590/s0037-86822010000400011 |
| Abstrakt: | Introduction: Visceral leishmaniasis (VL) is a neglected tropical disease with a complex immune response in different organs. This pattern of organ-specific immune response has never been evaluated in the gastrointestinal tract. The aim of this study was to determine the in situ immune response in duodenal biopsies on patients with VL. Methods: A case-control study was conducted on 13 patients with VL in comparison with nine controls. The immune response was evaluated using immunohistochemistry, for CD4, CD8, CD68, IL-4, IFN-gamma, TNF-alpha and IL-10. Histological findings from the villi, crypts and inflammatory process were analyzed. Results: All the cases of VL presented Leishmania antigens. No antigen was detected in the control group. The villus size was greater in the VL patients (p < 0.05). CD68 (macrophages) and CD4 levels were higher in the VL patients (p < 0.05). No differences in the expression of CD8, TNF-alpha, IL-10 or IL-4 were demonstrated. The number of cells expressing IFN-gamma was lower in the VL patients (p < 0.05). Conclusions: Low levels of cytokines were found in the gastrointestinal tract of patients with VL. This pattern was not found in other organs affected by the disease. Immunotolerance of this tissue against Leishmania could explain these findings, as occurs with intestinal bacteria. |
| Databáze: | MEDLINE |
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