| Autor: |
Lege-Oguntoye L; Department of Pharmacology, Ahmadu Bello University, Zaria., Onyemelukwe GC, Maiha BB, Udezue EO, Eckerbom S |
| Jazyk: |
angličtina |
| Zdroj: |
East African medical journal [East Afr Med J] 1990 Nov; Vol. 67 (11), pp. 770-8. |
| Abstrakt: |
In 17 semi-immune adult volunteers, chemoprophylaxis with 300 mg chloroquine base weekly for six months was found to be effective in suppressing malaria. However, following 3 months of chemoprophylaxis, a significant reduction of IFA titres was seen lasting up to 2 months after chloroquine withdrawal. There was resurgence of malaria in the post-intervention phase. 2 months after drug withdrawal, serum concentrations of IgG and factor B were significantly reduced. 3 months after initiation of chloroquine prophylaxis, a temporary but significant decrease of IgG and IgM serum concentrations was found with a corresponding decline in the number of B-lymphocytes and regulatory T-cells. These returned to normal at 6 months of chemoprophylaxis. Our findings suggest that short-term malaria chemoprophylaxis may significantly interfere with humoral and cell-mediated immunity in areas of intensive P. falciparum transmission. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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