Antibiotic prophylaxis in vaginal hysterectomy. Three doses of cefuroxime plus metronidazole versus one dose of ciprofloxacin.

Autor: Brouwer WK; Medical Centre, Leeuwarden, The Netherlands., Hoogkamp-Korstanje JA, Kuiper KM
Jazyk: angličtina
Zdroj: Pharmaceutisch weekblad. Scientific edition [Pharm Weekbl Sci] 1990 Dec 14; Vol. 12 (6A), pp. 292-4; discussion 294-5.
DOI: 10.1007/BF01967836
Abstrakt: The prophylactic efficacy of three intravenous doses of cefuroxime 1,500 mg plus metronidazole 500 mg in vaginal hysterectomy was compared with placebo in a prospective double-blind randomized study. Febrile morbidity occurred in 13 of 26 patients in the placebo group and 0 of 27 patients in the study group. In a second prospective randomized study, the efficacy of intravenous ciprofloxacin (200 mg single dose) was compared with the cefuroxime plus metronidazole regimen. Febrile morbidity was found in 3 of 54 patients in the ciprofloxacin group, but in none of the 58 patients in the cefuroxime plus metronidazole group.
Databáze: MEDLINE