Chromosome sequence maps of the Giardia lamblia assemblage A isolate WB.

Autor: Upcroft JA; Queensland Institute of Medical Research, Brisbane, Australia. Jacqui.Upcroft@qimr.edu.au, Krauer KG, Upcroft P
Jazyk: angličtina
Zdroj: Trends in parasitology [Trends Parasitol] 2010 Oct; Vol. 26 (10), pp. 484-91. Date of Electronic Publication: 2010 Aug 24.
DOI: 10.1016/j.pt.2010.07.002
Abstrakt: Two genotypes, assemblages A and B, of the pathogenic gut protozoan parasite Giardia lamblia infect humans. Symptoms of infection range from asymptomatic to chronic diarrhea. Giardia chromosomes have long been characterized but not until the publication of the first Giardia genome sequence was chromosome mapping work, commenced nearly two decades ago, completed. Initial mapping studies identified and ordered Not I chromosome segments (summating to 1.8 Mb) of the estimated 2 Mb chromosome 3. The resulting map was confirmed with the release of the Giardia genome sequence and this revitalized mapping. The result is that 93% of the WB isolate genome sequence has now been assigned to one of five major chromosomes, and community access to these data has been made available through GiardiaDB, the database for Giardia genomes.
(Copyright © 2010 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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