| Autor: |
Chernenkov AIu, Ivanova SV, Koval'tsova SV, Gracheva LM, Peshekhonov VT, Fedorova IV, Korolev VG |
| Jazyk: |
ruština |
| Zdroj: |
Genetika [Genetika] 2010 Jun; Vol. 46 (6), pp. 742-9. |
| Abstrakt: |
Gene HSM3 encodes the Hsm3 protein involved in the minor branch in the system responsible for the correction of mismatched bases in DNA structure and controls replicative and reparative spontaneous mutagenesis in yeast Saccharomyces cerevisiae. Spontaneous and UV-induced mutagenesis was studied in three mutant alleles of gene HSM3, and repair effectivity of artificial heteroduplexes was assessed in DNA molecule. The resuts of these studies allowed establishment of the protein domain structure of protein Hsm3 and functions of each domain: the N-terminal domain is responsible for binding to mispaired bases, and the C-terminal domain ensures the interaction with other proteins involved in the system of mismatched base correction. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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