| Autor: |
Baltadzheiva D, Penkova K, Stamenov G, Dimitrova D, Michailova A |
| Jazyk: |
bulharština |
| Zdroj: |
Akusherstvo i ginekologiia [Akush Ginekol (Sofiia)] 2010; Vol. 49 (4), pp. 12-7. |
| Abstrakt: |
It is now apparent that immunologic implantation failure and recurrent abortions are more than likely mediated through activation of natural killer (NK) cells. The NK cell activity is mediated by a balance between activating and inhibitory receptors upon recognition of MHC class I molecules. In this study, we investigated by flow cytometry the expression of activating and inhibitory receptors on NK cells of women with reproductive failures- recurrent spontaneous abortion (RSA) and implantation failures (IF). In women with implantation failures CD56+CD16+ NK cell subset was significantly increased (p = 0.017) and CD158a expressing NK cells was significantly decreased (p = 0.027). CD161-activating receptor expressing CD56+ NK cells were significantly decreased in women with RSA (p = 0.033). These data further support an imbalance in NK cell subsets in women with reproductive failures. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
