[Association of obstructive sleep apnea syndrome with the signs of nonalcoholic fatty liver disease and calculated glomerular filtration rate in metabolic syndrome].

Autor:	Severova MM, Fomin VV, Lebedeva MV, Sorokin IuD, Saginova EA, Minakova EG, Galliamov MG, Mukhin NA
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2010; Vol. 82 (6), pp. 35-9.
Abstrakt:	Aim: to assess a relationship between obstructive sleep apnea syndrome (OSAS) and the signs of nonalcoholic fatty liver disease (NAFLD) in patients with metabolic syndrome (MS). Material and Methods: Serum total cholesterol, triglycerides, high-density lipoprotein cholesterol concentrations, fasting blood glucose, ASAT, ALAT, gamma-glutamyl transpeptidase (gamma-GT), alkaline phosphatase (AP), total bilirubin, uricemia, and creatininemia were determined in 32 patients (mean age 47.6 +/- 9. 7 years) with MS. The authors also measured fasting blood insulin levels with the further calculation of the homeostatic model assessment (HOMA) index, as well as plasma C-peptide concentration. Abdominal ultrasound study and OSAS diagnosis by the routine scheme were made in all the patients. Results: OSAS was associated with the significant increase in the body mass index (40.5 +/- 9.4 and 31.9 +/- 4.6 kg/m2; p = 0.001), waist circumference (130.0 +/- 22.5 and 107.5 +/- 11.0 cm; p = 0.001), and C-peptide levels (1611.0 +/- 614.0 pmol/1; p = 0.019), and the serum activities of gamma-GT (117.0 +/- 57.0 and 42.01 +/- 14.0 IU/ml; p = 0.05) and AP (80.0 +/- 53.0 and 74.0 +/- 48.0 UI/ml; p = 0.05). The patients OSAS had also a significantly lower glomerular filtration rate (GFR) estimated using the modification of diet in renal disease (MDRD) formula (66.0 +/- 19.0 and 82.0 +/- 21.0 ml/min/1.73 m2; p < 0.05). Conclusion: The presence of OSAS in patients with MS is associated with the increase in laboratory signs of NAFLD and the decrease in the GFR calculated by the MDRD formula.
Databáze:	MEDLINE
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