Effect of goniothalamin on the development of Ehrlich solid tumor in mice.
| Autor: | Vendramini-Costa DB; Programa de Pós-graduação em Biologia Celular e Estrutural, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), CP 6109, 13083-970 Campinas, SP, Brazil., de Castro IB, Ruiz AL, Marquissolo C, Pilli RA, de Carvalho JE |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry [Bioorg Med Chem] 2010 Sep 15; Vol. 18 (18), pp. 6742-7. Date of Electronic Publication: 2010 Jul 27. |
| DOI: | 10.1016/j.bmc.2010.07.053 |
| Abstrakt: | In this work the antiproliferative activity of goniothalamin (1), both in racemic and in its enantiomeric pure forms, in a solid tumor experimental model using laboratory animals is described. The antiedematogenic activity displayed by racemic 1 in the carrageenan edema model in mice together with the reduction of Ehrlich solid tumor model suggest a relationship between anticancer and antiinflammatory activities with the antiinflammatory activity favoring the antiproliferative activity itself. (Copyright (c) 2010 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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