| Autor: |
Faria-Pinto Pd; Departamento de Bioquímica, Instituto de Ciências Biológicas, Laboratório de Estrutura e Função de Proteínas, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil., Mendes RG, Carvalho-Campos Cd, Maia AC, Oliveira AA, Coelho PM, Vasconcelos EG |
| Jazyk: |
angličtina |
| Zdroj: |
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2010 Jul; Vol. 105 (4), pp. 370-3. |
| DOI: |
10.1590/s0074-02762010000400004 |
| Abstrakt: |
In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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