Functional MRI in chronic epilepsy: associations with cognitive impairment.
| Autor: | Vlooswijk MC; Department of Neurology, Maastricht University Medical Centre, Maastricht, Netherlands., Jansen JF, de Krom MC, Majoie HM, Hofman PA, Backes WH, Aldenkamp AP |
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| Jazyk: | angličtina |
| Zdroj: | The Lancet. Neurology [Lancet Neurol] 2010 Oct; Vol. 9 (10), pp. 1018-27. Date of Electronic Publication: 2010 Aug 12. |
| DOI: | 10.1016/S1474-4422(10)70180-0 |
| Abstrakt: | Chronic epilepsy is frequently accompanied by serious cognitive side-effects. Clinical factors are important, but cannot account entirely for this cognitive comorbidity. Therefore, research is focusing on the underlying cerebral mechanisms to understand the development of cognitive dysfunction. In the past two decades, functional MRI techniques have been applied extensively to the study of cognitive impairment in chronic epilepsy. However, because of wide variation in study designs, analysis methods, and data presentation, interpretation of these studies has become increasingly difficult for clinicians. In patients with localisation-related epilepsy, whether findings of functional MRI represent the underlying neuronal substrate for cognitive decline remains a subject of debate. (Copyright © 2010 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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