| Autor: |
Kalapala SK; Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland., Hobbie SN, Böttger EC, Shcherbakov D |
| Jazyk: |
angličtina |
| Zdroj: |
PloS one [PLoS One] 2010 Aug 05; Vol. 5 (8), pp. e11960. Date of Electronic Publication: 2010 Aug 05. |
| DOI: |
10.1371/journal.pone.0011960 |
| Abstrakt: |
Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12. RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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