| Autor: |
Purtov KV, Petunin AI, Burov AE, Puzyr AP, Bondar VS |
| Jazyk: |
angličtina |
| Zdroj: |
Nanoscale research letters [Nanoscale Res Lett] 2010 Jan 19; Vol. 5 (3), pp. 631-636. Date of Electronic Publication: 2010 Jan 19. |
| DOI: |
10.1007/s11671-010-9526-0 |
| Abstrakt: |
Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bind to the target antigen immobilized on the Sepharose 6B matrix through antibody-antigen interaction. The idea can be extended to use nanodiamonds as carriers for delivery of bioactive substances (i.e., drugs) to various targets in vivo. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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