| Autor: |
Nassimizadeh M; Cardiovascular Medicine Group, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK., Ashrafian H, Drury NE, Howell NJ, Digby J, Pagano D, Frenneaux MP, Born GV |
| Jazyk: |
angličtina |
| Zdroj: |
Diabetes & vascular disease research [Diab Vasc Dis Res] 2010 Jul; Vol. 7 (3), pp. 213-5. Date of Electronic Publication: 2010 Jul 26. |
| DOI: |
10.1177/1479164110376207 |
| Abstrakt: |
Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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