| Autor: |
Koroleva OS, Zateĭshchikov DA |
| Jazyk: |
ruština |
| Zdroj: |
Kardiologiia [Kardiologiia] 2010; Vol. 50 (6), pp. 54-62. |
| Abstrakt: |
The review describes possible role of kinesins in development of coronary heart disease and efficacy of treatment with statins. Fourty five kinesins are represented in human body making up a superfamily of universal and simplest motor proteins which are expressed almost in all tissues. Level of kinesin 6 is 5% higher than expression of other kinesins in some segments of coronary arteries and it is relatively low in organs playing unknown role in susceptibility to atherosclerosis. As a result of several genoms wide association studies the role of polymorphic marker Thr719Arg of kinesin 6 gene in development of ischemic heart disease, myocardial infarction, and in efficacy of therapy with statins was revealed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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