Electrochemical determination of gatifloxacin, moxifloxacin and sparfloxacin fluoroquinolonic antibiotics on glassy carbon electrode in pharmaceutical formulations.

Autor: Radi AE; Department of Chemistry, Faculty of Science (Dumyat), Mansoura University, 34517 Dumyat, Egypt. abdradi@yahoo.com, Wahdan T, Anwar Z, Mostafa H
Jazyk: angličtina
Zdroj: Drug testing and analysis [Drug Test Anal] 2010 Aug; Vol. 2 (8), pp. 397-400.
DOI: 10.1002/dta.143
Abstrakt: Three fluoroquinolones; gatifloxacin (GAT), moxifloxacin (MOX) and sparfloxacin (SPAR) were electrochemically studied in various buffer systems at different pH values, using a glassy carbon electrode. The three fluoroquinolones were electrochemically oxidized at potential range (0.65-1.1 V) vs Ag-AgCl-KCl. The oxidation was irreversible and exhibited adsorption-controlled process behavior at all pH values and buffers studied. An electroanalytical methodology based on the adsorptive behavior of fluoroquinolones on glassy carbon electrode (GCE) and according to the linear relation between peak current and concentration using differential pulse voltammetry (DPV) method was successfully applied to the determination of the three fluoroquinolones in bulk and tablets. The proposed methods were statistically in agreement with that obtained by spectrophotometric comparison method.
(Copyright © 2010 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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