| Autor: |
Bustamante Montes LP; Universidad Autónoma del Estado de México, Toluca, Estado de México. patriciiab@yahoo.com.mx, Waliszewski S, Hernández-Valero M, Sanín-Aguirre L, Infanzón-Ruiz RM, Jañas AG |
| Jazyk: |
Spanish; Castilian |
| Zdroj: |
Ciencia & saude coletiva [Cien Saude Colet] 2010 Jun; Vol. 15 Suppl 1, pp. 1169-74. |
| DOI: |
10.1590/s1413-81232010000700025 |
| Abstrakt: |
Fetuses and children are more susceptible to the effects of environmental toxins. The objective of this article is to determine the levels of organochlorine pesticides (HCB, ss-HCH, pp'DDT, op'DDT and pp'DDE) in the serum lipids of mothers of newborns with cryptorchidism and compare the levels to a control group of mothers of newborns with descended testicles. The cases were composed of newborns with cryptorchidism (n=41), and the controls (n=41) newborns with descended testicles. Blood samples from both groups of mothers were used to determine the organochlorine pesticide levels. Cryptorchidism was diagnosed at birth by a neonatologist. The results showed that the organochlorine pesticide residues were found in the serum lipids of both groups of mothers. The median serum lipid levels (mgkg-1 lipid-based) were statistically higher for the metabolites pp'DDT (0.464 vs. 0.269) and ss-HCH (0.263 vs. 0.192) in the cryptorchidism group compared to the control group (p<0.01). It could be concluded that the levels of the metabolites pp'DDT and ss-HCH are higher among mothers of newborns with cryptorchidism. It is possible that substances with anti-androgenic effects could produce endocrine disruption, such as cryptorchidism, during fetal development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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