Latent cytomegalovirus infection amplifies CD8 T-lymphocyte mobilisation and egress in response to exercise.

Autor: Turner JE; School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK., Aldred S, Witard OC, Drayson MT, Moss PM, Bosch JA
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2010 Nov; Vol. 24 (8), pp. 1362-70. Date of Electronic Publication: 2010 Jul 16.
DOI: 10.1016/j.bbi.2010.07.239
Abstrakt: Exercise induces mobilisation of CD8(+) T lymphocytes (CD8TL) into the peripheral blood. This response is largely confined to effector-memory CD8TLs: antigen experienced cells which have a strong tissue-homing and effector potential. This study investigated whether effector-memory cells also account for the CD8TL egress from peripheral blood following exercise. As latent Cytomegalovirus (CMV) infection is associated with a robust expansion in the number and proportion of effector-memory CD8TLs, we also investigated if CMV serostatus was a determinant of the CD8TL responses to exercise. Fourteen males (Mean age 35, SD ± 14 yrs), half of whom were CMV seropositive (CMV(+)), ran on a treadmill for 60 min at 80% VO(2) max. Blood was collected at baseline, during the final minute of exercise, and 15 min and 60 min thereafter. CD8TL memory subsets were characterised by flow cytometry, using the cell-surface markers CD45RA, CD27, and CD28. The results confirmed that CD8TLs with an effector-memory phenotype (CD27(-)CD28(-)CD45RA(+/-)) exhibited the largest increase during exercise (+200% to +250%), and also showed the largest egress from blood 60 min post-exercise (down to 40% of baseline values). Strikingly, the mobilisation and subsequent egress of total CD8TLs was nearly twice as large in CMV(+) individuals. This effect appeared specific to CD8TLs, and was not seen for CD4(+) T lymphocytes or total lymphocytes. This effect of CMV serostatus was largely driven by the higher numbers of exercise-responsive effector-memory CD8TLs in the CMV(+) participants. This is the first study to demonstrate that infection history is a determinant of immune system responses to exercise.
(Copyright © 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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