Pro-healing potential of hemin: an inducer of heme oxygenase-1.

Autor: Ahanger AA; Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar (UP), Pin 243 122, India., Prawez S, Leo MD, Kathirvel K, Kumar D, Tandan SK, Malik JK
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2010 Oct 25; Vol. 645 (1-3), pp. 165-70. Date of Electronic Publication: 2010 Jul 16.
DOI: 10.1016/j.ejphar.2010.06.048
Abstrakt: Hemin induces heme oxygenase (HO), an enzyme which degrades heme in a rate-limiting manner and has an important role in cellular protection against oxidative stress and apoptosis. This HO inducer may be of potential therapeutic value in wound healing and inflammation. To identify the beneficial activity of HO vis a vis wound healing, hemin was used as inducer of HO in rats using a full-thickness cutaneous wound model. Hemin treatment increased cellular proliferation and collagen synthesis as evidenced by increase in wound contraction and hydroxyproline and glucosamine contents. mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-alpha and up-regulation of anti-inflammatory cytokine IL-10.
(Copyright 2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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