| Autor: |
Zhukov VA, Shishkina LN, Safatov AS, Sergeev AA, P'iankov OV, Petrishchenko VA, Zaĭtsev BN, Toporkov VS, Sergeev AN, Nesvizhskiĭ IuV, Vorob'ev AA |
| Jazyk: |
ruština |
| Zdroj: |
Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 2010 (5), pp. 24-9. |
| Abstrakt: |
The paper presents results of testing a modified algorithm for predicting virus ID50 values in a host of interest by extrapolation from a model host taking into account immune neutralizing factors and thermal inactivation of the virus. The method was tested for A/Aichi/2/68 influenza virus in SPF Wistar rats, SPF CD-1 mice and conventional ICR mice. Each species was used as a host of interest while the other two served as model hosts. Primary lung and trachea cells and secretory factors of the rats' airway epithelium were used to measure parameters needed for the purpose of prediction. Predicted ID50 values were not significantly different (p = 0.05) from those experimentally measured in vivo. The study was supported by ISTC/DARPA Agreement 450p. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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