| Autor: |
Ye QS; Kunming Institute of Precious Metals, 650106, Kunming, China., Liu WP, Chen XZ, Yu Y, Chang QW, Hou SQ |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of pharmacal research [Arch Pharm Res] 2010 Jun; Vol. 33 (6), pp. 807-11. Date of Electronic Publication: 2010 Jul 06. |
| DOI: |
10.1007/s12272-010-0602-x |
| Abstrakt: |
A novel mixed NH(3)/NH(2)OH platinum(II) complex cis-[Pt(NH(3))(NH(2)OH)Cl(2)] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and (1)H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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