Sortase transpeptidases: insights into mechanism, substrate specificity, and inhibition.
| Autor: | Clancy KW; Department of Chemistry, Duke University, Durham, NC, USA., Melvin JA, McCafferty DG |
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| Jazyk: | angličtina |
| Zdroj: | Biopolymers [Biopolymers] 2010; Vol. 94 (4), pp. 385-96. |
| DOI: | 10.1002/bip.21472 |
| Abstrakt: | Gram-positive bacteria pose a serious healthcare threat. The growing antibiotic resistance epidemic creates a dire need for new antibiotic targets. The sortase family of enzymes is a promising target for antimicrobial therapy. This review covers the current knowledge of the mechanism, substrate specificity, and inhibitory studies of the Gram-positive bacterial [corrected] enzyme sortase. (Copyright (c) 2010 Wiley Periodicals, Inc.) |
| Databáze: | MEDLINE |
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