| Autor: |
Bobylev AG, Marsagishvili LG, Shpagina MD, Romanova VS, Kotel'nikova RA, Podlubnaia ZA |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2010 May-Jun; Vol. 55 (3), pp. 394-9. |
| Abstrakt: |
The antiamyloidogenic capacity of water-soluble nitroderivatives of fullerene C60: methyl ester of LN-[(2-nitroglyceryl) fullerenyl] proline, methyl ester of LN-[(2,3-dinitroglyceryl) fullerenyl] proline, and 2 nitroxyethyl ether LN-([2-(nitroxy) ethyl] fullerenyl) proline has been studied in vitro by high-resolution electron microscopy. It was shown that these fullerene C60 nitroderivatives are able to prevent the formation of amyloid fibrils by the brain Abeta(1-42)-peptide and muscle X-protein and to destroy mature fibrils. Electron microscopy is a promising method for selecting effective antiamyloidogenic drugs. The antiamyloidogenic activity of nanodimensional fullerene C60 nitroderivatives offers strong possibilities for creating a new nanotechnology for the therapy of amyloidoses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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