Growth factors, adiponectin, leptin and body mass index in pre-pubertal children born large for gestational age.

Autor: Challa AS; Pediatric Research Laboratory, Child Health Department, University of Ioannina, Ioannina, Greece., Evagelidou EN, Giapros VI, Cholevas VI, Andronikou SK
Jazyk: angličtina
Zdroj: Journal of endocrinological investigation [J Endocrinol Invest] 2011 Jun; Vol. 34 (6), pp. 411-6. Date of Electronic Publication: 2010 Jun 28.
DOI: 10.3275/7138
Abstrakt: Objective: To examine whether the IGF axis in pre-pubertal children born large for gestational age (LGA) differs from that of those born appropriate for gestational age (AGA).
Research Design and Methods: The study population consisted of 98 non-obese children aged 5.5-8 yr, of whom 37 were LGA, with birth weight (BW) > 90th percentile, and 61 AGA. The LGA children were subdivided into two subgroups, with BW 90th-97th percentile (no.=24) and BW > 97th percentile (no.=13), respectively. Total and free IGF-I, their binding proteins 1 and 3 (IGFBP-1 and IGFBP-3), leptin, adiponectin, fasting glucose (GF) and insulin (IF) were measured, and the homeostasis model assessment for insulin resistance (HOMA-IR index) was determined.
Results: IGF-I, free IGF-I and IGFBP-1 were similar in both groups. Both LGA subgroups had lower IGFBP-3 levels than the AGA group (2.34 ± 0.61 and 2.70 ± 0.90, respectively, vs 3.92 ± 1.1 μg/ml, p < 0.01). Adiponectin was higher in the 90th-97th percentile LGA subgroup than the AGA group (p<0.01). GF and IF were higher in the LGA group (86.5 ± 5.6 mg/dl, p < 0.01, and 5.84 ± 2.13 μU/ml, respectively, p < 0.05) than in the AGA group (82.6 ± 7.7 mg/dl and 4.62 ± 1.9 μU/ml, respectively), as was the HOMA-IR index (1.27 ± 0.60 vs 0.94 ± 0.43, p < 0.01). These three parameters were also found higher in the >97th percentile LGA subgroup.
Conclusion: The IGF axis was not different in pre-pubertal children born LGA or AGA, with the exception of IGFBP-3, which was lower in the LGA children. In LGA pre-pubertal children the severity of intrauterine overgrowth was associated with the insulin resistance indices.
Databáze: MEDLINE
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