Effect of celecoxib combined with thoracic epidural analgesia on pain after thoracotomy.

Autor:	Senard M; Department of Anaesthesia and Intensive Care Medicine, Thoracic and Vascular Surgery, CHU de Liège, University of Liège, Domaine du Sart-Tilman, Liege, Belgium., Deflandre EP, Ledoux D, Roediger L, Hubert BM, Radermecker M, Libbrecht D, Joris JL
Jazyk:	angličtina
Zdroj:	British journal of anaesthesia [Br J Anaesth] 2010 Aug; Vol. 105 (2), pp. 196-200. Date of Electronic Publication: 2010 Jun 25.
DOI:	10.1093/bja/aeq129
Abstrakt:	Background: Thoracotomy results in severe postoperative pain potentially leading to chronic pain. We investigated the potential benefits of oral celecoxib on postoperative analgesia combined with thoracic epidural analgesia (TEA). Methods: Forty patients undergoing thoracotomy were included in this prospective, randomized, double-blind, placebo-controlled study. General anaesthesia was standardized. Patient-controlled epidural analgesia (T4-T5) was used during 48 h after surgery (ropivacaine 2 mg ml(-1) with sufentanil 0.5 microg ml(-1)). Patients were allocated to receive oral celecoxib or placebo from the evening before surgery until 48 h after operation. Postoperative pain scores, respiratory function, and morbidity were compared between the two groups. Results: Postoperative pain scores at rest (P=0.026) and during coughing (P=0.021) were lower and patient satisfaction was greater (P=0.0033) in the celecoxib group. Consumption of the local anaesthetic solution was comparable between groups. Postoperative restrictive pulmonary syndrome and morbidity were comparable between groups. Conclusions: Celecoxib improves postoperative analgesia provided by TEA after thoracotomy.
Databáze:	MEDLINE
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