Serum oxidative stress is increased in patients with post cholecystectomy bile duct injury.
| Autor: | Miranda-Díaz AG; General Surgery, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, México. alexmiranda1@hotmail.com, Hermosillo-Sandoval JM, Ortiz GG, Lizardi-García D, Cardona-Muñoz EG, Pacheco-Moisés F |
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| Jazyk: | angličtina |
| Zdroj: | Revista espanola de enfermedades digestivas [Rev Esp Enferm Dig] 2010 Jun; Vol. 102 (6), pp. 352-6. |
| DOI: | 10.4321/s1130-01082010000600002 |
| Abstrakt: | Background: Post-cholecystectomy bile duct injuries are identified by the onset of jaundice as well as elevated bilirubin and alkaline phosphatase levels during the peri-operative period. It is unknown how serum oxidative stress markers are modified in patients with post-cholecystectomy bile duct injuries. Objective: To determine serum oxidative stress marker levels (lipid peroxidation by-products, nitrites/nitrates and total antioxidant capacity) in patients with post-cholecystectomy bile duct injuries. Patients and Methods: A prospective, transversal and analytical study was designed with two groups. Group 1: 5 healthy volunteer subjects. Group 2: 52 patients with post-cholecystectomy bile duct injuries (43 female and 9 male). An elective bilio-digestive reconstruction was performed at week 8. The serum oxidative stress marker levels were quantified by colorimetric method. Results: Patients with bile duct injuries had a significant increased serum lipid peroxides (malondialdehyde and 4-hydroxy-alkenals) and nitric oxide metabolites (nitrites/nitrates) levels compared to the control group. In contrast, total antioxidant capacity in patients with bile duct injuries remained similar compared to healthy controls. Conclusions: The results show that oxidative stress is usually associated to bile duct injury. |
| Databáze: | MEDLINE |
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