Suspected antidepressant-induced switch to mania in unipolar depression: a first-person narrative.

Autor: Amey C; catherine@redgraphite.co.uk
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2010 Sep; Vol. 125 (1-3), pp. 111-5. Date of Electronic Publication: 2010 Jun 08.
DOI: 10.1016/j.jad.2010.05.004
Abstrakt: Background: Antidepressant-induced switch to mania has not been thoroughly characterized in bipolar disorder and is even less well understood in unipolar depression.
Method and Results: I describe, as a first-person narrative, my own experience of psychotic mania, which was suspected to have been induced by the tricyclic antidepressant, dosulepin. I have had a 16-year history of depression and was receiving sertraline 50 mg od when I was prescribed, off licence, dosulepin 25 mg 1-2 nocte for insomnia. Within days, I developed mild hypomanic symptoms and returned to my GP, who discontinued dosulepin but continued treatment with sertraline. I was also referred for psychiatric assessment. Two months later, I was detained under Section II of the Mental Health Act 1983 and admitted to hospital with psychotic manic symptoms.
Conclusion: More understanding of antidepressant-induced switch to mania is needed in unipolar depression. My case study highlights the need for prompt specialist care for patients with depression reporting even mild, sub-threshold symptoms of mania.
(2010 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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