| Autor: |
Bainbridge MN; Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. bainbrid@bcm.edu, Wang M, Burgess DL, Kovar C, Rodesch MJ, D'Ascenzo M, Kitzman J, Wu YQ, Newsham I, Richmond TA, Jeddeloh JA, Muzny D, Albert TJ, Gibbs RA |
| Jazyk: |
angličtina |
| Zdroj: |
Genome biology [Genome Biol] 2010; Vol. 11 (6), pp. R62. Date of Electronic Publication: 2010 Jun 17. |
| DOI: |
10.1186/gb-2010-11-6-r62 |
| Abstrakt: |
We have developed a solution-based method for targeted DNA capture-sequencing that is directed to the complete human exome. Using this approach allows the discovery of greater than 95% of all expected heterozygous singe base variants, requires as little as 3 Gbp of raw sequence data and constitutes an effective tool for identifying rare coding alleles in large scale genomic studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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