Prognostic value of lymph node ratio in poor prognosis node-positive breast cancer patients in Saudi Arabia.
| Autor: | Ibrahim EM; Department of Oncology, King Faisal Specialist Hospital and Research Center, Jeddah, Kingdom of Saudi Arabia., Elkhodary TR, Zekri JM, Bahadur Y, El-Sayed ME, Al-Gahmi AM, Rizvi SA, Hassouna AH, Fawzy EE, Awadalla SS |
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| Jazyk: | angličtina |
| Zdroj: | Asia-Pacific journal of clinical oncology [Asia Pac J Clin Oncol] 2010 Jun; Vol. 6 (2), pp. 130-7. |
| DOI: | 10.1111/j.1743-7563.2010.01288.x |
| Abstrakt: | Aim: Women in Saudi Arabia develop breast cancer at a young age with high prevalence of poor prognostic features. Because of such features, it is necessary to examine prognostic factors in this population. One such factor is the prognostic role of lymph node ratio (LNR). Methods: We performed retrospective analyses of patients with invasive non-metastatic breast cancer who underwent axillary lymph node dissection and had one or more positive axillary lymph nodes. Results: Two hundred and seventeen patients were considered eligible for the analysis. The median age was 46 years. At a median follow-up of 39.8 months, the median disease-free survival (DFS) was 67.3 months (95% CI, 50.4 to 84.3 months). Neither the classification of patients based on positive lymph node (pN) staging system, nor the absolute number of pN prognosticated DFS. Conversely, age Conclusion: Analysis of survival outcome of mostly young patients with early breast cancer identified adverse prognostic variables affecting DFS. If the utility of the derived model including LNR is proven in a larger patient population, it may replace the use of absolute number of positive axillary lymph nodes. |
| Databáze: | MEDLINE |
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