Are presynaptic proteins predisposed to self-assemble?
| Autor: | Goldstein AY; FM Kirby Neurobiology Center of Children's Hospital, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Schwarz TL |
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| Jazyk: | angličtina |
| Zdroj: | Neuron [Neuron] 2010 Jun 10; Vol. 66 (5), pp. 624-7. |
| DOI: | 10.1016/j.neuron.2010.05.021 |
| Abstrakt: | Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon. (Copyright 2010 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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