[Acute renal failure following Chlamydia pneumoniae pneumonia in a child].

Autor: Nasser H; Unité de néphrologie et de dialyse pédiatrique, médecine infantile I, hôpital d'Enfants, CHU de Nancy, Nancy, France. drhnasser@hotmail.com, Dib Nehme G, Camoin-Schweitzer MC, Andre JL
Jazyk: francouzština
Zdroj: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2010 Aug; Vol. 17 (8), pp. 1153-5. Date of Electronic Publication: 2010 Jun 11.
DOI: 10.1016/j.arcped.2010.05.003
Abstrakt: Acute renal failure (ARF) following Chlamydia pneumoniae pneumonia is rarely reported in adults. We present an observation in a 10-year-old child, who had C. pneumoniae pneumonia treated with roxithromycin for a period of 10 days, without any other nephrotoxic drug, in particular nonsteroidal anti-inflammatory drugs. At the end of antibiotic treatment, he presented with asthenia, polyuria, polydipsia, increased plasma creatinine, metabolic acidosis, hypokalemia, and markers of tubular damage. The etiological investigations showed positive C. pneumoniae antibodies, increased serum concentrations of C3 and C4 complement, IgA, and IgG. No uveitis was noted. The diagnosis was tubulointerstitial nephropathy after C. pneumoniae pneumonia. C. pneumoniae pneumonia should be considered a differential diagnosis of community-acquired pneumonia, especially in cases of poor response to conventional antibiotic therapy. It may be associated with tubulointerstitial nephropathy and/or rapidly progressive glomerulonephritis whose severity varies in children as in adults. Early and effective treatment of C. pneumoniae infection with macrolide antibiotics usually provides favorable progression of renal function.
(Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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