Lung transplantation with grafts from elderly donors: a single-center experience.

Autor: Dezza MC; Chirurgia III, Centro Trapianto di Fegato e di Polmone, Ospedali Riuniti di Bergamo, Italy., Parigi PC, Corno V, Lucianetti A, Pinelli D, Zambelli M, Guizzetti M, Aluffi A, Tagliabue F, Platto M, Codazzi D, Triggiani M, Colledan M
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2010 May; Vol. 42 (4), pp. 1262-4.
DOI: 10.1016/j.transproceed.2010.03.093
Abstrakt: Introduction: Use of extended criteria donors is one of the strategies to face the scarcity of donors for lung transplantation.
Methods: Between November 2002 and May 2009, we performed 52 LTs in 50 recipients, 10 of whom (group A) received lungs from donors aged 55 years or older (median, 58.5; range, 56-66 years) for comparison with 28 patients (group B) transplanted with lungs from donors younger than 55 years (median, 25.5; range, 15-54 years). We excluded 9 children and 3 recipients of combined liver plus lung transplantations from the study.
Results: Recipient age, gender, and indications for transplantation did not differ significantly between the 2 groups. Neither were there significant differences in PaO2/FiO2 ratios before lung retrieval, or length of the ischemic time The first PaO2/FiO2 on arrival to the intensive care unit (ICU) and the median length of ICU stay were similar. All patients, except 2 who died in the operating theatre, were extubated between 3 and 216 hours after the transplantation. Hospital mortality was similar in both groups: 3 patients in group A and 2 in group B (P = .1). The median portions of the predicted 1-second forced expiratory volume (FEV1) at 6 months after transplantation did not differ in the 2 groups: 62.4% in group A versus 70% in group B (P = .85).
Conclusion: Lung grafts from donors older than 55 years can be effectively used for transplantation, thus increasing the total organ pool.
(Copyright (c) 2010 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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