| Autor: |
Michels TD; Department of Chemistry, The University of California, Irvine, California 92697-2025, USA., Kier MJ, Kearney AM, Vanderwal CD |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2010 Jul 02; Vol. 12 (13), pp. 3093-5. |
| DOI: |
10.1021/ol101035p |
| Abstrakt: |
Short formal syntheses of the antitumor antibiotics porothramycins A and B from a commercially available ester of the unnatural amino acid 3-(3-pyridyl)alanine are presented. A rearrangement cascade that presumably involves a Zincke-type pyridinium ring-opening followed by cyclization of a pendant nucleophilic amide generates the salient pyrroline ring of the alkaloids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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