| Autor: |
Redford PS; Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK., Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, O'Garra A |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of immunology [Eur J Immunol] 2010 Aug; Vol. 40 (8), pp. 2200-10. |
| DOI: |
10.1002/eji.201040433 |
| Abstrakt: |
IL-10 regulates the balance of an immune response between pathogen clearance and immunopathology. We show here that Mycobacterium tuberculosis (Mtb) infection in the absence of IL-10 (IL-10(-/-) mice) results in reduced bacterial loads in the lung. This reduction was preceded by an accelerated and enhanced IFN-γ response in the lung, an increased influx of CD4(+) T cells into the lung, and enhanced production of chemokines and cytokines, including CXCL10 and IL-17, in both the lung and the serum. Neutralization of IL-17 affected neither the enhanced production of CXCL10 nor the accumulation of IFN-γ-producing T cells in the lungs, but led to reduced numbers of granulocytes in the lung and reduced bacterial loads in the spleens of Mtb-infected mice. This suggests that IL-17 may contribute to dissemination of Mtb. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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