HPLC and TLC enantioseparation of the nitro-positioned aryloxysubstituted aminopropanols.

Autor: Cizmáriková R; Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. cizmarikova@fpharm.uniba.sk, Bruchatá K, Pastírová Z, Lehotay J, Hrobonová K
Jazyk: angličtina
Zdroj: Die Pharmazie [Pharmazie] 2010 May; Vol. 65 (5), pp. 387-8.
Abstrakt: An enantioseparation study of nitro-substituted aryloxyaminopropanols was performed using HPLC on a teicoplanin chiral stationary phase and TLC impregnated with L-aspartic and L-tartaric acid as chiral selectors. The type of substituent on the nitrogen in the hydrophilic part of molecule is essential for excellent separation by HPLC. L-aspartic acid seems to be a suitable chiral selector for enantioseparation by TLC.
Databáze: MEDLINE