[Women, schizophrenia and oestrogen; neurobiological hypotheses and hormonetherapy studies].

Autor:	Boerma MA; m.boerma@ggzingeest.nl, van der Stel JC, van Amelsvoort T, Linszen DH, de Haan L
Jazyk:	Dutch; Flemish
Zdroj:	Tijdschrift voor psychiatrie [Tijdschr Psychiatr] 2010; Vol. 52 (4), pp. 235-44.
Abstrakt:	Background: Gender differences play a role in the origin and course of schizophrenia. It has been hypothesised that the gonadal hormone, oestrogen, may possibly perform a protective function in the development of certain forms of schizophrenia. Aim: To review neurobiological hypotheses concerning the role of oestrogen in the development and course of schizophrenia. Method: The relevant literature was consulted with the help of PubMed, textbooks and bibliographic references; the search terms used were 'oestrogen', 'schizophrenia', 'gender', 'epigenetics', 'psychosis', 'women' and 'brain'. There were no restrictions with regards to the time-period. Results: Neuro-imaging, animal experiments and hormone-therapy studies showed several effects of oestrogen in the field of epigenetics, morphology of the brain, interaction with neurotransmitters and neuroprotection. Conclusion: Oestrogen is an important link in a complex of factors that clearly play a role in the varying development of schizophrenia in men and women. So far, however, there is insufficient evidence to support the existence of a specific mechanism that would explain why oestrogen may perform a protective function in schizophrenia.
Databáze:	MEDLINE
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