| Autor: |
Ito M; Department of Virology I, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan., Takasaki T, Kotaki A, Tajima S, Yuwono D, Rimal HS, dos Santos F, de Jesus MD, Lina BB, Tsuda Y, Lim CK, Nerome R, Calerés A, Shindo N, Drager RD, Andjaparidze A, Kurane I |
| Jazyk: |
angličtina |
| Zdroj: |
Japanese journal of infectious diseases [Jpn J Infect Dis] 2010 May; Vol. 63 (3), pp. 181-4. |
| Abstrakt: |
A severe dengue outbreak occurred in East Timor in 2005. The dengue virus genome was detected by TaqMan RT-PCR in 40 serum samples, as follows: dengue virus type-3 (DENV-3) in 37 samples, DENV-2 in 2 samples, and DENV-1 in one sample. One DENV-1 genome, one DENV-2 genome, and 5 DENV-3 genomes were sequenced, and these specimens were aligned with the previously determined envelope (E) gene sequences. The DENV-1 strain belonged to genotype IV and was close to those previously isolated in Indonesia and Australia. The DENV-2 strain belonged to genotype I and was close to those previously isolated in Indonesia, Australia, the Far East, and India in 1993-2001. The DENV-3 strain belonged to genotype I and was close to those previously isolated in Indonesia. The results indicate that the dengue outbreak was caused mainly by DENV-3, with DENV-1 and DENV-2 as minor serotypes, and suggest that these strains of 3 serotypes of DENV entered East Timor from neighboring countries, co-circulated, and caused the dengue outbreak in 2005. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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