| Autor: |
Fueri C; INSERM-U6 and CNRS-GR45, 280 Bd Sainte-Marguerite, 13009 Marseille, France., Faudon M, Barrit MC, Hery F |
| Jazyk: |
angličtina |
| Zdroj: |
Neurochemistry international [Neurochem Int] 1985; Vol. 7 (5), pp. 843-52. |
| DOI: |
10.1016/0197-0186(85)90040-3 |
| Abstrakt: |
Serotonin of the superior cervical ganglion is contained in a distinct and separate population of small intensely fluorescent (SIF) cells. We provide evidence, in in vitro experiments, that newly synthesized serotonin can be released in the cat superior cervical ganglion from the serotonin-containing SIF cells. Resting steady state in the release of [(3)H]serotonin was observed 30 min after the beginning of the superfusion with l-[(3)H]tryptophan. A marked increase was seen in the serotonin release either in the presence of fluoxetine, a potent reuptake blocker of serotonin, or during depolarization with potassium chloride or veratridine. Calcium-free medium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by tetrodotoxin. Paradoxically, a slight increase in the spontaneous release of serotonin was observed in the presence of tetrodotoxin. Serotonin released from serotonin-containing SIF cells could be involved in the modulation of ganglionic transmission. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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