| Autor: |
Fung SC; University Laboratory of Physiology, Parks Rd, Oxford OX1 3PT, U.K., Swarbrick MJ, Fillenz M |
| Jazyk: |
angličtina |
| Zdroj: |
Neurochemistry international [Neurochem Int] 1985; Vol. 7 (1), pp. 155-63. |
| DOI: |
10.1016/0197-0186(85)90020-8 |
| Abstrakt: |
The release of [(3)H]noradrenaline from rat hippocampal synaptosomes by 25 mM K(+) and 5 ?M veratridine, but not by the Ca(2+) ionophore A23187 was depressed by baclofen. This depression was reversed by 8-Bromo-cAMP. This action of baclofen was stereospecific and mimicked both that of GABA in the presence of bicuculline and that of clonidine. The ?(2)-adrenoceptor antagonists yohimbine and Wy25309 antagonised the action of clonidine and baclofen but not that of GABA. Specific binding of [(3)H]clonidine was displaced by Wy25309 and baclofen, but not by GABA. Specific binding of [(3)H]GABA in the presence of Ca(2+) was displaced by baclofen but not by Wy25309. It is concluded that baclofen is not a specific agonist at GABA(B) receptors in the brain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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