| Autor: |
Koh WW; MRC/UCL Centre for Medical Molecular Virology, University College London, London W1T 4JF, UK., Forsman A, Hué S, van der Velden GJ, Yirrell DL, McKnight A, Weiss RA, Aasa-Chapman MM |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of general virology [J Gen Virol] 2010 Sep; Vol. 91 (Pt 9), pp. 2374-80. Date of Electronic Publication: 2010 May 19. |
| DOI: |
10.1099/vir.0.022228-0 |
| Abstrakt: |
Human immunodeficiency virus type 1 (HIV-1) is classified into different phylogenetic subtypes, with subtype C representing more than half of the novel infections globally. However, there are relatively few subtype C envelopes available for study. We amplified 18 unique env genes from 13 patients who were infected with subtype C HIV-1 in six African countries and in Scotland to create replication-competent viruses. These envelopes are phylogenetically diverse across the subtype C spectrum, and have on average more N-linked glycosylation sites and slightly longer variable loops than previously described C envelopes. We found that CCR3 coreceptor usage is less prevalent in subtype C than in subtype B viruses, and these envelopes have varied sensitivity to neutralization. The subtype C chimeric viruses generated in this study will be useful for evaluating the breadth of neutralizing antibodies and other entry inhibitors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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