| Autor: |
Teslenko VI; Bogolyubov Institute for Theoretical Physics, National Academy of Science of Ukraine, 14-b Metrologichna Street, 03680 Kyiv, Ukraine., Petrov EG, Verkhratsky A, Krishtal OA |
| Jazyk: |
angličtina |
| Zdroj: |
Physical review letters [Phys Rev Lett] 2010 Apr 30; Vol. 104 (17), pp. 178105. Date of Electronic Publication: 2010 Apr 29. |
| DOI: |
10.1103/PhysRevLett.104.178105 |
| Abstrakt: |
A novel physical mechanism is proposed to explain the temperature-independent transition reactions in molecular systems. The mechanism becomes effective in the case of conformation transitions between quasi-isoenergetic molecular states. It is shown that at room temperatures, stochastic broadening of molecular energy levels predominates the energy of low-frequency vibrations accompanying the transition. This leads to a cancellation of temperature dependence in the stochastically averaged rate constants. As an example, a physical interpretation of temperature-independent onset of P2X{3} receptor desensitization in neuronal membranes is provided. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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