A draft sequence of the Neandertal genome.

Autor: Green RE; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Krause J; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Briggs AW; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Maricic T; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Stenzel U; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Kircher M; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Patterson N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhai W; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA., Fritz MH; European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK., Hansen NF; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Durand EY; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA., Malaspinas AS; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA., Jensen JD; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA., Marques-Bonet T; Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.; Institute of Evolutionary Biology (UPF-CSIC), Dr. Aiguader 88, 08003 Barcelona, Spain., Alkan C; Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Prüfer K; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Meyer M; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Burbano HA; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Good JM; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.; Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA., Schultz R; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Aximu-Petri A; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Butthof A; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Höber B; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Höffner B; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Siegemund M; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Weihmann A; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Nusbaum C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lander ES; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Russ C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Novod N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Affourtit J; 454 Life Sciences, Branford, CT 06405, USA., Egholm M; 454 Life Sciences, Branford, CT 06405, USA., Verna C; Department of Human Evolution, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Rudan P; Croatian Academy of Sciences and Arts, Zrinski trg 11, HR-10000 Zagreb, Croatia., Brajkovic D; Croatian Academy of Sciences and Arts, Institute for Quaternary Paleontology and Geology, Ante Kovacica 5, HR-10000 Zagreb, Croatia., Kucan Ž; Croatian Academy of Sciences and Arts, Zrinski trg 11, HR-10000 Zagreb, Croatia., Gušic I; Croatian Academy of Sciences and Arts, Zrinski trg 11, HR-10000 Zagreb, Croatia., Doronichev VB; ANO Laboratory of Prehistory, St. Petersburg, Russia., Golovanova LV; ANO Laboratory of Prehistory, St. Petersburg, Russia., Lalueza-Fox C; Institute of Evolutionary Biology (UPF-CSIC), Dr. Aiguader 88, 08003 Barcelona, Spain., de la Rasilla M; Área de Prehistoria Departamento de Historia Universidad de Oviedo, Oviedo, Spain., Fortea J; Área de Prehistoria Departamento de Historia Universidad de Oviedo, Oviedo, Spain., Rosas A; Departamento de Paleobiología, Museo Nacional de Ciencias Naturales, CSIC, Madrid, Spain., Schmitz RW; Der Landschaftverband Rheinlund-Landesmuseum Bonn, Bachstrasse 5-9, D-53115 Bonn, Germany.; Abteilung für Vor- und Frühgeschichtliche Archäologie, Universität Bonn, Germany., Johnson PLF; Department of Biology, Emory University, Atlanta, GA 30322, USA., Eichler EE; Howard Hughes Medical Institute, Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Falush D; Department of Microbiology, University College Cork, Cork, Ireland., Birney E; European Molecular Biology Laboratory-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK., Mullikin JC; Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Slatkin M; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA., Nielsen R; Department of Integrative Biology, University of California, Berkeley, CA 94720, USA., Kelso J; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Lachmann M; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany., Reich D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Pääbo S; Department of Evolutionary Genetics, Max-Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2010 May 07; Vol. 328 (5979), pp. 710-722.
DOI: 10.1126/science.1188021
Abstrakt: Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development. We show that Neandertals shared more genetic variants with present-day humans in Eurasia than with present-day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.
Databáze: MEDLINE