Click glycoconjugation of per-azido- and alkynyl-functionalized beta-peptides built from aspartic acid.

Autor: Barra M; Clermont Université, Université Blaise Pascal, Laboratoire SEESIB, BP 10448, F-63000, Clermont-Ferrand, France., Roy O, Traïkia M, Taillefumier C
Jazyk: angličtina
Zdroj: Organic & biomolecular chemistry [Org Biomol Chem] 2010 Jun 28; Vol. 8 (13), pp. 2941-55. Date of Electronic Publication: 2010 May 04.
DOI: 10.1039/b923275c
Abstrakt: Azide- and alkynyl-containing homo-beta(3)-peptides, of up to six residues in length, were synthesised in solution from aspartic acid. Their subsequent conjugation with monosaccharides bearing an azide or a terminal alkyne function was efficiently achieved by copper-mediated cycloadditions leading to two novel families of small glycoclusters. These compounds represent ideal tools to explore carbohydrate-mediated multivalent interactions.
Databáze: MEDLINE