Intima-media thickness of the common carotid artery is not significantly higher in Crohn's disease patients compared to healthy population.

Autor: Broide E; Institute of Gastroenterology, Liver Diseases and Nutrition, Assaf Harofeh Medical Center, 70300, Zerifin, Israel. efibroide@yahoo.com, Schopan A, Zaretsky M, Kimchi NA, Shapiro M, Scapa E
Jazyk: angličtina
Zdroj: Digestive diseases and sciences [Dig Dis Sci] 2011 Jan; Vol. 56 (1), pp. 197-202. Date of Electronic Publication: 2010 May 01.
DOI: 10.1007/s10620-010-1235-0
Abstrakt: Background: Patients with Crohn's disease might have accelerated atherosclerosis due to: chronic systemic inflammation, metabolic changes or prolonged steroid treatment.
Aims: The aim of this study was to assess the risk of sub-clinical atherosclerosis in Crohn's disease, by measuring the intima-media thickness and peak systolic velocity of the common carotid artery.
Methods: Fifty Crohn's disease patients aged between 20 and 45 years were compared to 25 controls. Patients with a family history of cardiovascular diseases or a known risk for atherosclerosis were excluded. All participants underwent nutritional assessment. Carotid artery ultrasonography was performed and intima-media thickness and peak systolic velocity were measured, proximal to the common carotid bifurcation. Clinical data and laboratory parameters (hemoglobin, highly sensitive C-reactive protein, and plasma homocysteine) were determined.
Results: No significant differences between the groups were found for intima-media thickness or peak systolic velocity. Multiple regression analysis revealed a positive correlation of intima-media thickness with older age. Peak systolic velocity was negatively associated with age.
Conclusions: Crohn's disease patients do not have an increased risk for developing early atherosclerosis.
Databáze: MEDLINE
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